🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareConstipation on GLP-1: pathophysiology and evidence-based management — November 2025 Page 2

Constipation on GLP-1: pathophysiology and evidence-based management — November 2025

kevin_tulsa Mon, Jun 23, 2025 at 9:07 PM 12 replies 1,370 viewsPage 2 of 3
NicoleRaleigh
Member
356
1,567
Aug 2024
Raleigh, NC
Jun 23, 2025 at 11:57 PM#6

Saving this for reference. Quality thread.

45 19InsuranceTom, WendyG_ATL, SaraMom3 and 42 others
Reply Quote Save Share Report
Dr.SleepRoch
Senior Member
1,123
5,678
Apr 2024
Rochester, MN
Jun 24, 2025 at 12:14 AM#7

Slightly tangential to Constipation on GLP-1 but carlos_SATX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

25 8kim_atl_prep, sarah_TO, wendy_avl and 22 others
Reply Quote Save Share Report
RickReta_CO
Member
312
1,234
Jan 2025
Colorado
Jun 24, 2025 at 12:31 AM#8

+1 to carlos_SATX. Especially the point about "A few questions about your Constipation ..." — I have seen the same in my own experience with Constipation on GLP-1.

2 14hyun_seoul, jim_asheville
Reply Quote Save Share Report
nick_SD_fit
Member
278
1,234
Sep 2024
San Diego, CA
Jun 24, 2025 at 12:48 AM#9

LipidDoc_ATL — that is really helpful context on Constipation on GLP-1. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

38 0PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 35 others
Reply Quote Save Share Report
Dr.SurgeonPGH
Senior Member
1,345
6,789
Mar 2024
Pittsburgh, PA
Jun 24, 2025 at 1:05 AM#10

To answer RickReta_CO's question specifically:

From a clinical standpoint, Constipation on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Jun 24, 2025 at 4:05 AM
22 13B12Beth, RickReta_CO, PharmHunterJen and 19 others
Reply Quote Save Share Report

Similar Threads

SELECT trial 4-year follow-up data released — sustained MACE reduction16 replies
GLP-1 receptor agonists and thyroid C-cell concerns — evidence review19 replies
Is there a ceiling effect for GLP-1-mediated weight loss?20 replies
Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide6 replies
My 18-month semaglutide journey — comprehensive data log20 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register