Feb 1, 2025 at 7:44 AM#41
Saving this for reference. Top-tier content.
23 23Dr.PainCLE, mike_mealprep, NicoleRaleigh and 20 others
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Feb 1, 2025 at 8:01 AM#42
Slightly tangential to Orforglipron and hepatic but SarahChen_PharmD reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
27 15NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 24 others
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Feb 1, 2025 at 8:18 AM#43
Saving this for reference. Quality thread.
41 4pam_columbus, nick_SD_fit, ben_calgary and 38 others
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Feb 1, 2025 at 8:35 AM#44
Want to share my personal experience related to Orforglipron and hepatic since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 287 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 10 months later: I am down 47 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Orforglipron and aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
Last edited: Feb 1, 2025 at 2:35 PM
23 18MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 20 others
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Feb 1, 2025 at 8:52 AM#45
Relevant to Orforglipron and hepatic — here is my latest bloodwork comparison:
Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
16 5NicoleRaleigh, james_edin, FranDenver and 13 others
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