To answer robert_kc's question specifically:
From a clinical standpoint, Orforglipron and hepatic is an area where we have good evidence.
The short answer: baseline labs + quarterly monitoring is the standard of care.
The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.
NicoleRaleigh said:5%, triglycerides 213 → 113 mg/dL, hsCRP 8
This is exactly right. NicoleRaleigh articulated what I have been trying to explain to my doctor for months. The Orforglipron and hepatic aspect is the most important factor.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Orforglipron and hepatic.
To answer Dr.EM_Chicago: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
robert_kc said:Top-tier content
This is exactly right. robert_kc articulated what I have been trying to explain to my friends for months. The Orforglipron and hepatic aspect is what made the difference for me.
This thread is incredible for Orforglipron and info. Better than most online groups.