OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Orforglipron and hepatic.
To answer sarah_TO: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to Orforglipron and hepatic — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
Slightly tangential to Orforglipron and hepatic but carl_compliance reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Dr.EM_Chicago said:Thank you all for the thoughtful replies on Orforglipron and hepatic
This is exactly right. Dr.EM_Chicago articulated what I have been trying to explain to my doctor for months. The Orforglipron and hepatic aspect is the most important factor.