May 14, 2026 at 1:05 PM#6
Subscribing to this thread. Pharmacogenomics of GLP-1 is exactly what I've been researching. 🙏
Last edited: May 14, 2026 at 4:05 PM
30 9jim_asheville, matt_MKE, Dr.ReproEndo and 27 others
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May 14, 2026 at 1:22 PM#7
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Pharmacogenomics of GLP-1.
To answer Dr.ObesityMed: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
27 8KristenIndy, MarkLI_maint, Dr.PeteFamMed and 24 others
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May 14, 2026 at 1:39 PM#8
Adding my data to this Pharmacogenomics of GLP-1 discussion:
| Metric | Baseline | Month 4 | Month 8 |
|---|---|---|---|
| Weight | 274 lbs | 229 lbs | 199 lbs |
| A1C | 6.8% | 6.2% | 5.4% |
| hsCRP | 8.0 | 3.0 | 0.8 |
Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.
40 7LindaRN_retired, tommy_boulder, hyun_seoul and 37 others
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May 14, 2026 at 1:56 PM#9
+1 to GenomicsKate. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Pharmacogenomics of GLP-1.
8 18LibrarianMeg, bri_stats, pete_manc_UK and 5 others
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May 14, 2026 at 2:13 PM#10
Slightly tangential to Pharmacogenomics of GLP-1 but Dr.ReproEndo reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
25 15BrianDallas92, labquiet_amy, emily_PDX and 22 others
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