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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — 12 month update Page 3

Incretin effect in healthy vs T2DM — 12 month update

marco_milano Mon, Oct 20, 2025 at 2:49 AM 28 replies 1,548 viewsPage 3 of 6
KevinCompounds
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Oct 20, 2025 at 7:04 AM#11
TrialTracker_MD said:
Incretin effect in healthy vs T2DM is not that straightforward in my experience

This is exactly right. TrialTracker_MD articulated what I have been trying to explain to my friends for months. The Incretin effect in aspect is what made the difference for me.

Last edited: Oct 20, 2025 at 9:04 AM
46 0jennifer_SEA, tyler_CSCS, VanRx_Mike and 43 others
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TomTeleRx
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Oct 20, 2025 at 7:21 AM#12

Reading this thread on Incretin effect in hits close to home. Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 72 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Incretin effect in — take the leap. It was the best health decision I have ever made. ❤️

36 5bri_stats, pete_manc_UK, anna.melb_AU and 33 others
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SteveThurs
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Oct 20, 2025 at 7:38 AM#13

lisa_labSD — that is really helpful context on Incretin effect in. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

44 14SleepFixSam, PurityPaulOR, MaxMetOK and 41 others
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anna.melb_AU
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Oct 20, 2025 at 7:55 AM#14

To answer TomTeleRx's question specifically:

From a clinical standpoint, Incretin effect in healthy vs is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

42 8tammy_FL, Dr.LipidDallas, alex_tucson and 39 others
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hyun_seoul
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Oct 20, 2025 at 8:12 AM#15

Bookmarked 📌 The Incretin effect in info in this thread is essential. Coming back to this for sure.

Last edited: Oct 20, 2025 at 12:12 PM
35 24LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 32 others
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