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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — 12 month update Page 6

Incretin effect in healthy vs T2DM — 12 month update

marco_milano Mon, Oct 20, 2025 at 2:49 AM 28 replies 1,548 viewsPage 6 of 6
TomTeleRx
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Oct 20, 2025 at 11:19 AM#26

+1. This mirrors my journey exactly. The Incretin effect in discussion here is so valuable.

Last edited: Oct 20, 2025 at 12:19 PM
22 18pete_manc_UK, anna.melb_AU, mark_tokyo and 19 others
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Dr.SurgeonPGH
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Oct 20, 2025 at 11:36 AM#27
jim_asheville said:
Night shift nurse — I started at 287 lbs and felt like I would tried everything

I respect jim_asheville perspective but I think this oversimplifies things a bit. Re: Incretin effect in healthy vs — the effect size varies considerably by population.

I am not saying jim_asheville wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

23 22TomTeleRx, DoseLogDan, SleepFixSam and 20 others
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VanRx_Mike
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Vancouver, CA
Oct 20, 2025 at 11:53 AM#28

Reading this thread on Incretin effect in hits close to home. Dad of 2 checking in — I started at 273 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 48 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Incretin effect in — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Oct 20, 2025 at 2:53 PM
13 1Admin, Dr.Martinez, mike_mod and 10 others
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lucas_SP_BR
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São Paulo, BR
Oct 20, 2025 at 12:10 PM#29

Bookmarked 📌 The Incretin effect in info in this thread is essential. Coming back to this for sure.

Last edited: Oct 20, 2025 at 2:10 PM
22 23KarenAZ_mom, zoe_NC, Dr.ObesityLA and 19 others
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TomFromTexas
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Austin, TX
Oct 20, 2025 at 12:27 PM#30

TomTeleRx — that is really helpful context on Incretin effect in. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

37 17BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 34 others
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