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ForumsOff-TopicCoffee and GLP-1 — has your caffeine tolerance changed?

Coffee and GLP-1 — has your caffeine tolerance changed?

NurseAsh_DET Sat, May 30, 2026 at 11:39 AM 8 replies 296 viewsPage 1 of 2
NurseAsh_DET
Member
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Sep 2024
Detroit, MI
May 30, 2026 at 1:04 PM#1

Hey everyone. I have been on tirzepatide for about 6 months now and wanted to get the community's take on something.

Coffee and GLP-1 — has your caffeine tolerance changed?

I have been reading through old threads but have not found exactly what I'm looking for. My situation: I have been wondering about coffee and glp-1 has your caffeine and I am not sure what to make of it.

Has anyone else dealt with this? What was your experience? My PCP was not super helpful — just said to "monitor it" which is not exactly actionable advice lol.

Any input appreciated. Thanks in advance. 🙏

26 7FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 23 others
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LipidDoc_ATL
Senior Member
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5,678
Apr 2024
Atlanta, GA
May 30, 2026 at 1:21 PM#2

Good question. For Coffee and GLP-1 has your caffeine, here is what the evidence says:

  • The clinical trial data (SURMOUNT program) supports this approach
  • Real-world results from this community generally confirm the trial findings
  • Individual variation is real — give it at least 8 weeks before judging

Happy to go deeper on any of these points if helpful.

3 15traveltech_sara, AttorneyGrant, DebRD_ATL
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carlos_SATX
Member
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1,123
Oct 2024
San Antonio, TX
May 30, 2026 at 1:38 PM#3

To answer the question about Coffee and GLP-1 has your caffeine tolerance changed? — in my experience this comes down to a few key factors.

I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on Coffee and GLP-1 has your seems solid.

What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest NurseAsh_DET try the same approach and reporting back.

21 10Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 18 others
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Dr.SportsMedIN
Senior Member
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6,789
Feb 2024
Indianapolis, IN
May 30, 2026 at 1:55 PM#4

Coffee and GLP-1 has your caffeine — I actually dealt with this exact situation around month 3.

Short answer: talk to your prescriber first. Longer answer: I wrote about my experience in the results forum if you want the full details.

38 8Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 35 others
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TomFromTexas
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May 2024
Austin, TX
May 30, 2026 at 2:12 PM#5

Slightly tangential to Coffee and GLP-1 has but LipidDoc_ATL reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: May 30, 2026 at 4:12 PM
14 6BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 11 others
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