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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingBatch-to-batch purity variation — looking for input Page 3

Batch-to-batch purity variation — looking for input

Dr.EndoIndy Mon, May 26, 2025 at 6:39 AM 17 replies 1,487 viewsPage 3 of 4
mel_PDX
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Dec 2024
Portland, OR
May 26, 2025 at 10:54 AM#11

Dr.AddMedPHL — wow. I've been looking for this exact info for weeks.

Last edited: May 26, 2025 at 4:54 PM
47 24Dr.NateNeph, PharmD_Rodriguez, julia.endo and 44 others
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maya_sedona
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Sep 2024
Sedona, AZ
May 26, 2025 at 11:11 AM#12

Slightly tangential to Batch-to-batch purity but Dr.EndoIndy reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

38 10NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 35 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
May 26, 2025 at 11:28 AM#13

Thanks for sharing this, Dr.EndoIndy. A few questions about your Batch-to-batch experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Batch-to-batch?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: May 26, 2025 at 5:28 PM
47 2WendyG_ATL, SaraMom3, Dr.MetabolicMD and 44 others
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Dr.EndoIndy
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Oct 2024
Indianapolis, IN
May 26, 2025 at 11:45 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Batch-to-batch purity.

To answer maya_sedona: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

18 23DeniseRN_TPA, SandraNC_45, Dr.EndoIndy and 15 others
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Dr.RaviCardio
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May 26, 2025 at 12:02 PM#15

Relevant to Batch-to-batch purity — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 227 → 97 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: May 26, 2025 at 1:02 PM
31 21jason_sac26, chris_chi24, tampaLisa73 and 28 others
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