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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingCOA red flag compilation — what worked for you? Page 5

COA red flag compilation — what worked for you?

Dr.PathRoch Wed, Feb 18, 2026 at 8:28 AM 28 replies 1,232 viewsPage 5 of 6
FranDenver
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Feb 18, 2026 at 3:33 PM#21

lori_vegas — that is really helpful context on COA red flag compilation . Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

44 10Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 41 others
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GenomicsKate
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Feb 18, 2026 at 3:50 PM#22

To answer PedsEndoPhilly's question specifically:

From a clinical standpoint, COA red flag compilation what is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

18 14KristenIndy, MarkLI_maint, Dr.PeteFamMed and 15 others
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Dr.PulmRoch
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Feb 18, 2026 at 4:07 PM#23

Thank you FranDenver! This is incredibly helpful. Bookmarking for later. 🙏

29 6AttorneyGrant, DebRD_ATL, KristenIndy and 26 others
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FDA_TrackerJim
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Feb 18, 2026 at 4:24 PM#24

Relevant to COA red flag compilation what — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 241 → 111 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

16 6Dr.LeslieOBGYN, MikeNYC_runner and 13 others
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mike_mod
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Feb 18, 2026 at 4:41 PM#25

Slightly tangential to COA red flag compilation but FranDenver reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 18, 2026 at 6:41 PM
20 23PurityPaulOR, MaxMetOK, MounjBrad and 17 others
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