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ForumsSide Effects & ManagementDay 3 on sema and I feel like death warmed over — need advice

Day 3 on sema and I feel like death warmed over — need advice

roxy_nash Sat, Aug 16, 2025 at 7:33 AM 50 replies 2,150 viewsPage 1 of 10
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roxy_nash
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890
Dec 2024
Nashville, TN
Aug 16, 2025 at 8:58 AM#1

Can I just vent for a second about day 3 on sema and i?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily — just solidarity. Anyone else going through this right now?

11 4josh_phd_bmore, roxy_nash, tony_orlando and 8 others
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TirzTom
Senior Member
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9,876
Feb 2024
Florida
Online
Aug 16, 2025 at 9:15 AM#2

roxy_nash's experience with Day 3 on sema and I feel resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I am on a different medication. But the overall trajectory has been remarkably similar. Down 55 lbs in 10 months.

One thing I would add that roxy_nash did not mention: my sleep quality improved dramatically.

44 1tom_AK, josh_phd_bmore, roxy_nash and 41 others
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CryptoCarl
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May 2024
Arizona
Aug 16, 2025 at 9:32 AM#3

Thanks for sharing this, roxy_nash. A few questions about your Day 3 on sema and I experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Day 3 on sema?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

22 17AussieAnna, BethLabQueen, ChrisMacros and 19 others
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roxy_nash
Member
178
890
Dec 2024
Nashville, TN
Aug 16, 2025 at 9:49 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Day 3 on sema and I feel.

To answer CryptoCarl: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

7 14Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 4 others
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anders_CPH
Senior Member
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Feb 2024
Copenhagen, DK
Aug 16, 2025 at 10:06 AM#5

Adding my data to this Day 3 on sema and I feel discussion:

MetricBaselineMonth 5Month 8
Weight278 lbs238 lbs203 lbs
A1C7.2%6.0%5.4%
hsCRP7.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

28 6ChrisMacros, KetoKyle, CanadaChris and 25 others
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