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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsFrom 310 to 198 in 15 months — what worked for you? Page 2

From 310 to 198 in 15 months — what worked for you?

MikeNYC_runner Tue, Dec 2, 2025 at 1:49 AM 13 replies 1,241 viewsPage 2 of 3
Dr.NutriCornell
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Dec 2, 2025 at 4:39 AM#6
Dr.SurgeonPGH said:
— in my experience this comes down to a few key factors

Gonna push back on this one. From 310 to 198 in 15 months what is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

4 11emily_PDX, Dr.SleepRoch, laura_annarbor and 1 other
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anders_CPH
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Dec 2, 2025 at 4:56 AM#7

Adding my data to this From 310 to 198 in 15 discussion:

MetricBaselineMonth 5Month 8
Weight266 lbs236 lbs221 lbs
A1C7.0%6.0%5.4%
hsCRP5.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

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LindaRN_retired
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Sarasota, FL
Dec 2, 2025 at 5:13 AM#8

hyun_seoul — wow. I've been looking for this exact info for weeks.

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AttorneyGrant
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Washington, DC
Dec 2, 2025 at 5:30 AM#9

Slightly tangential to From 310 to 198 in 15 but RegAffairsDC reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Dec 2, 2025 at 6:30 AM
18 0pat_auckland, Dr.GastroMayo, JakeBK_lifts and 15 others
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mike_mod
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Dec 2, 2025 at 5:47 AM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

34 19PurityPaulOR, MaxMetOK, MounjBrad and 31 others
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