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ForumsSide Effects & ManagementWhen to stop GLP-1 — need advice Page 7

When to stop GLP-1 — need advice

pam_stl Mon, Oct 20, 2025 at 2:04 AM 39 replies 1,952 viewsPage 7 of 8
marcus_mpls
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Minneapolis, MN
Oct 20, 2025 at 11:59 AM#31

Slightly tangential to When to stop GLP-1 need but Dr.SurgeonPGH reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

14 0bbq_ray_KC, oliver_london, tane_welly and 11 others
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mike_nyc
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Oct 20, 2025 at 12:16 PM#32

Saving this for reference. Top-tier content.

15 22stefan_berlin, Dr.EM_Chicago, pete_RVA and 12 others
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pam_stl
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Oct 2024
St. Louis, MO
Oct 20, 2025 at 12:33 PM#33

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on When to stop GLP-1 need.

To answer pam_stl: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Oct 20, 2025 at 5:33 PM
34 0PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 31 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Oct 20, 2025 at 12:50 PM#34

Relevant to When to stop GLP-1 need — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 223 → 93 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Oct 20, 2025 at 6:50 PM
30 2SaraMom3, Dr.MetabolicMD, RetaRick_CA and 27 others
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FDA_TrackerJim
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Feb 2024
Rockville, MD
Oct 20, 2025 at 1:07 PM#35

Want to share my personal experience related to When to stop GLP-1 need since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 264 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 49 lbs, my labs have normalized, and I am off 2 of my 3 medications. The When to stop GLP-1 aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

13 1jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 10 others
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