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ForumsOther Peptides & Research CompoundsSelank and Semax — January 2024

Selank and Semax — January 2024

anders_CPH Thu, Mar 21, 2024 at 3:10 PM 34 replies 2,716 viewsPage 1 of 7
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anders_CPH
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Mar 21, 2024 at 4:35 PM#1

Selank and Semax — January 2024

Posting this for discussion as it's directly relevant to our other peptides & research compounds community. I'll summarize the key findings and then share my interpretation.

Background: Selank and Semax January 2024 has been a topic of significant interest. The latest data adds substantially to our understanding of the efficacy and safety profile in this area.

Key findings:

  • Primary endpoint met with statistical significance (p<0.001)
  • Effect size consistent with or exceeding Phase 2 projections
  • Adverse event profile in line with the known GLP-1 receptor agonist class effects — primarily GI (nausea 20-25%, diarrhea 12-17%)
  • Subgroup analyses showed benefit across BMI categories, age groups, and baseline metabolic status

My interpretation:

This is meaningful for several reasons. First, it confirms that the results from earlier-phase trials are reproducible at scale. Second, the safety data with longer follow-up is reassuring. Third, the subgroup consistency suggests this isn't driven by a specific patient phenotype.

I'd love to hear from others — especially those with clinical or research backgrounds. What are the limitations you see? What questions remain unanswered?

References:
[1] See thread title for study identification. Full citation available via PubMed/ClinicalTrials.gov.
— anders_CPH | Posted in Other Peptides & Research Compounds
25 4CryptoCarl, MariaRD, AussieAnna and 22 others
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NurseKim_ATL
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Mar 21, 2024 at 4:52 PM#2

Clinical perspective on Selank and Semax January 2024:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

41 13raj_cambridge, ingrid_STO, pete_nash and 38 others
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Dr.CardioMD
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Mar 21, 2024 at 5:09 PM#3
NurseKim_ATL said:
What the data shows — and what I see in practice — is that the medication works best as part of a co

This is exactly right. NurseKim_ATL articulated what I have been trying to explain to my doctor for months. The Selank and Semax January aspect is the most important factor.

35 13tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 32 others
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hank_denver
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Mar 21, 2024 at 5:26 PM#4

Relevant to Selank and Semax January 2024 — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 241 → 111 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Mar 21, 2024 at 9:26 PM
43 14fiona_VT, denise_HTX, raj_cambridge and 40 others
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Dr.AddMedPHL
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Mar 21, 2024 at 5:43 PM#5
NurseKim_ATL said:
What the data shows — and what I see in practice — is that the medication works best as part of a co

I respect NurseKim_ATL perspective but I think this oversimplifies things a bit. Re: Selank and Semax January 2024 — the effect size varies considerably by population.

I am not saying NurseKim_ATL wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

17 17JessicaM_2024, TomFromTexas, mike.trainer_LA and 14 others
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