May 17, 2026 at 7:22 AM#11
DataDave — wow. This community is amazing.
22 8mike_mealprep, NicoleRaleigh, james_edin and 19 others
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May 17, 2026 at 7:39 AM#12
Slightly tangential to 18-month transformation but JakeSmashed95 reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
22 1julia.endo, JessicaM_2024, TomFromTexas and 19 others
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May 17, 2026 at 7:56 AM#13
Thanks for sharing this, JakeSmashed95. A few questions about your 18-month transformat experience:
- What dose did you start at?
- How long before you noticed side effects improving?
- Did your provider have any specific recommendations about 18-month transf?
I am in a similar boat and trying to learn from others' experiences before my next appointment.
Last edited: May 17, 2026 at 8:56 AM
29 23oliver_london, tane_welly, Dr.PathRoch and 26 others
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May 17, 2026 at 8:13 AM#14
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on 18-month transformation .
To answer MeganSA_TX: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
11 20Dr.LipidDallas, alex_tucson, kevin_tulsa and 8 others
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May 17, 2026 at 8:30 AM#15
Relevant to 18-month transformation 127 — here is my latest bloodwork comparison:
Key improvements: A1C 8.4% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
42 22EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 39 others
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