Just wanted to say — for anyone reading this Marathon PR after 80 thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪
Want to share my personal experience related to Marathon PR after 80 lbs since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 259 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 8 months later: I am down 39 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Marathon PR after 80 aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
Clinical perspective on Marathon PR after 80 lbs weight loss :
I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.
For this specific question, I would recommend: reviewing the relevant clinical guidelines.
Thank you TomTeleRx! This is incredibly helpful. Taking this to my next appointment. 🙏
Relevant to Marathon PR after 80 lbs — here is my latest bloodwork comparison:
Key improvements: A1C 7.2% → 5.3%, triglycerides 207 → 107 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.