MikeFit_NJ — that is really helpful context on A1C reduction on. Follow-up question: how long did you wait before increasing your dose?
I am in a similar situation (week 4) and trying to set realistic expectations.
To answer MarkLI_maint's question specifically:
From a clinical standpoint, A1C reduction on semaglutide is a reasonable concern that deserves a thorough answer.
The short answer: the evidence supports this approach for most patients.
The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.
Thank you LondonLisa! This is incredibly helpful. Taking this to my next appointment. 🙏
Relevant to A1C reduction on semaglutide — here is my latest bloodwork comparison:
Key improvements: A1C 8.0% → 5.3%, triglycerides 247 → 117 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
Slightly tangential to A1C reduction on but LondonLisa reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.