🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Semaglutide cardiovascular benefit: SELECT trial deep dive Page 5

Semaglutide cardiovascular benefit: SELECT trial deep dive

Dr.CardioMD Sun, May 31, 2026 at 8:37 PM 21 replies 414 viewsPage 5 of 5
sean_dublin
Member
212
890
Nov 2024
Dublin, IE
Jun 1, 2026 at 3:42 AM#21

mike_mod — that is really helpful context on Semaglutide. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Jun 1, 2026 at 4:42 AM
45 18hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 42 others
Reply Quote Save Share Report
KevinCompounds
VIP Member
5,432
18,234
Dec 2023
Nevada
Jun 1, 2026 at 3:59 AM#22

To answer NicoleRaleigh's question specifically:

From a clinical standpoint, Semaglutide cardiovascular is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

49 12Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 46 others
Reply Quote Save Share Report
sarah.morrison
VIP Member
3,212
14,567
Jan 2024
California
Online
Jun 1, 2026 at 4:16 AM#23

Thank you sean_dublin! This is incredibly helpful. Taking this to my next appointment. 🙏

1 6tony_orlando
Reply Quote Save Share Report
SleepDoc_PDX
Member
289
1,234
Sep 2024
Portland, OR
Jun 1, 2026 at 4:33 AM#24

Relevant to Semaglutide cardiovascular — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 239 → 109 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

7 6sophie_paris, mel_PDX, Dr.AddMedPHL and 4 others
Reply Quote Save Share Report
BiostatsBrad
Member
456
2,345
Jul 2024
Durham, NC
Jun 1, 2026 at 4:50 AM#25

Slightly tangential to Semaglutide but sean_dublin reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

23 20NicoleRaleigh, james_edin, FranDenver and 20 others
Reply Quote Save Share Report
1345

Similar Threads

STEP 1-5 trials comprehensive summary — efficacy endpoints compiled12 replies
Oral semaglutide 50mg Phase 3 — OASIS program results16 replies
Semaglutide pharmacokinetics — half-life, Tmax, steady state modeling10 replies
Compounded semaglutide stability data — temperature and light sensitivity16 replies
0.25mg → 2.4mg titration: optimal schedule based on clinical data6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register