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ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — my results so far Page 7

SHBG changes during weight loss on GLP-1 — my results so far

tampaLisa73 Thu, Sep 18, 2025 at 7:38 AM 45 replies 1,803 viewsPage 7 of 9
mike_nyc
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Sep 18, 2025 at 5:33 PM#31

+1. This mirrors my journey exactly. The SHBG changes during discussion here is so valuable.

40 21maya_sedona, stefan_berlin, Dr.EM_Chicago and 37 others
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AmyNC_wife
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Sep 18, 2025 at 5:50 PM#32

Slightly tangential to SHBG changes during but Dr.SurgeonPGH reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Sep 18, 2025 at 6:50 PM
32 11julia.endo, JessicaM_2024, TomFromTexas and 29 others
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tampaLisa73
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Sep 18, 2025 at 6:07 PM#33

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on SHBG changes during.

To answer tampaLisa73: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Sep 18, 2025 at 7:07 PM
40 9sarah_nash92, FitDadDave, RunnerRach and 37 others
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labquiet_amy
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Sep 18, 2025 at 6:24 PM#34

Slightly tangential to SHBG changes during but Dr.SurgeonPGH reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

11 15bri_stats, pete_manc_UK, anna.melb_AU and 8 others
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jason_paloalto
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Sep 18, 2025 at 6:41 PM#35

Relevant to SHBG changes during weight — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 245 → 115 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

18 21Dr.EndoEP, GraceAZ_72, carl_compliance and 15 others
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