Just wanted to say — for anyone reading this Is it normal for thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪
Want to share my personal experience related to Is it normal for liver enzymes since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 265 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 14 months later: I am down 60 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Is it normal for aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
Clinical perspective on Is it normal for liver enzymes to go UP:
I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.
For this specific question, I would recommend: reviewing the relevant clinical guidelines.
Thank you Dr.PathRoch! This is incredibly helpful. Taking this to my next appointment. 🙏
Relevant to Is it normal for liver enzymes — here is my latest bloodwork comparison:
Key improvements: A1C 7.2% → 5.3%, triglycerides 243 → 113 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.