Aug 25, 2025 at 4:47 AM#6
Congrats MikeNYC_runner!! Keep going — you're doing incredible. 🎉
Last edited: Aug 25, 2025 at 6:47 AM
7 20SkepticalSean, Dr.CardioMD, EndoResFellow and 4 others
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Aug 25, 2025 at 5:04 AM#7
Clinical perspective on NNT for MACE prevention 6 month update:
I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.
For this specific question, I would recommend: reviewing the relevant clinical guidelines.
28 11tommy_boulder, hyun_seoul, jim_asheville and 25 others
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Aug 25, 2025 at 5:21 AM#8
100%. My provider said the same thing about NNT for MACE.
14 5julia.endo, JessicaM_2024, TomFromTexas and 11 others
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Aug 25, 2025 at 5:38 AM#9
Reading this thread on NNT for MACE prevention hits close to home. Dad of 2 checking in — I started at 285 lbs and felt like I would tried everything.
11 months on tirz and I am a different person. Not just the 60 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about NNT for MACE — take the leap. It was the best health decision I have ever made. ❤️
1 24sean_dublin
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Aug 25, 2025 at 5:55 AM#10
nick_SD_fit said:Keep going — you're doing incredible
This is exactly right. nick_SD_fit articulated what I have been trying to explain to my doctor for months. The NNT for MACE prevention aspect is the most important factor.
20 14pat_auckland, Dr.GastroMayo, JakeBK_lifts and 17 others
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