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ForumsCardiovascular OutcomesHeart failure hospitalization reduction on semaglutide — looking for input Page 5

Heart failure hospitalization reduction on semaglutide — looking for input

marcus_mpls Wed, Sep 10, 2025 at 6:31 PM 28 replies 1,408 viewsPage 5 of 6
emily_PDX
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Sep 11, 2025 at 1:36 AM#21

ZaraB_AL — that is really helpful context on Heart failure. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

50 22julia.endo, JessicaM_2024, TomFromTexas and 47 others
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PharmacoVig_BOS
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Feb 2024
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Sep 11, 2025 at 1:53 AM#22

To answer stefan_berlin's question specifically:

From a clinical standpoint, Heart failure hospitalization is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

26 7Dr.GutHealth, amsterdam_pete, LondonLisa and 23 others
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SteveThurs
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Sep 11, 2025 at 2:10 AM#23

Thank you emily_PDX! This is incredibly helpful. Taking this to my next appointment. 🙏

16 23SleepFixSam, PurityPaulOR, MaxMetOK and 13 others
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labquiet_amy
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Sep 11, 2025 at 2:27 AM#24

Relevant to Heart failure hospitalization — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 207 → 107 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

17 22bri_stats, pete_manc_UK, anna.melb_AU and 14 others
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wanda_boise
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Boise, ID
Sep 11, 2025 at 2:44 AM#25

Slightly tangential to Heart failure but emily_PDX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Sep 11, 2025 at 7:44 AM
10 21ben_calgary, patPC_UT, Dr.DermMIA and 7 others
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