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ForumsCardiovascular OutcomesGLP-1 and atrial fibrillation risk — 6 month update

GLP-1 and atrial fibrillation risk — 6 month update

Dr.LeslieOBGYN Thu, Mar 19, 2026 at 9:46 AM 12 replies 852 viewsPage 1 of 3
Dr.LeslieOBGYN
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Dallas, TX
Mar 19, 2026 at 11:11 AM#1

Trying to decide between options regarding glp-1 and atrial fibrillation risk 6 and could use some input from people who have been there.

My situation: been on sema for 6 months considering a switch.

I have read the wiki and FAQ but real-world experiences would help me make a decision. What would you do in my position?

50 8Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 47 others
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LipidDoc_ATL
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Apr 2024
Atlanta, GA
Mar 19, 2026 at 11:28 AM#2

Dr.LeslieOBGYN's experience with GLP-1 and atrial resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 36 lbs in 11 months.

One thing I would add that Dr.LeslieOBGYN did not mention: the relationship with food fundamentally changed.

37 3traveltech_sara, AttorneyGrant, DebRD_ATL and 34 others
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chris_chi24
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Sep 2024
Chicago, IL
Mar 19, 2026 at 11:45 AM#3

Thanks for sharing this, Dr.LeslieOBGYN. A few questions about your GLP-1 and atrial experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about GLP-1 and atria?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Mar 19, 2026 at 2:45 PM
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Dr.LeslieOBGYN
Member
567
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May 2024
Dallas, TX
Mar 19, 2026 at 12:02 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and atrial.

To answer chris_chi24: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

27 14NicoleRaleigh, james_edin, FranDenver and 24 others
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lucas_SP_BR
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Jun 2024
São Paulo, BR
Mar 19, 2026 at 12:19 PM#5

Relevant to GLP-1 and atrial fibrillation — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 249 → 119 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

38 5tampaLisa73, KarenAZ_mom, zoe_NC and 35 others
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