NNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 246 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 81 lbs, my labs have normalized, and I am off 2 of my 3 medications. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

JakeSmashed95 — that is really helpful context on NNT for MACE prevention . Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 263 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 88 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

paul_denver — that is really helpful context on NNT for MACE prevention . Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 280 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 40 lbs, my labs have normalized, and I am off 2 of my 3 medications. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.