OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Small molecule vs peptide.
To answer VendorMark: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Adding my data to this Small molecule vs peptide discussion:
| Metric | Baseline | Month 4 | Month 8 |
|---|---|---|---|
| Weight | 246 lbs | 241 lbs | 211 lbs |
| A1C | 7.0% | 6.2% | 5.4% |
| hsCRP | 5.0 | 3.0 | 1.2 |
Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.
Subscribing to this thread. Small molecule vs peptide is exactly what I've been researching. 🙏
Slightly tangential to Small molecule vs peptide but mia_MS2 reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
+1 to claudia_zurich. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Small molecule vs peptide.