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ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 6

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Sat, Oct 19, 2024 at 12:13 AM 31 replies 2,377 viewsPage 6 of 7
sarah_TO
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Sep 2024
Toronto, CA
Oct 19, 2024 at 8:43 AM#26

+1 to paige_pharma. Especially the point about "This is incredibly helpful..." — I have seen the same in my own experience with Has anyone dealt with.

Last edited: Oct 19, 2024 at 12:43 PM
1 11andrew_nyc
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JenPlateau
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Nov 2024
Missouri
Oct 19, 2024 at 9:00 AM#27

Bookmarked 📌 The Has anyone dealt info in this thread is essential. Coming back to this for sure.

9 21TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 6 others
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Dr.AddMedPHL
Senior Member
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Mar 2024
Philadelphia, PA
Oct 19, 2024 at 9:17 AM#28

Clinical perspective on Has anyone dealt with rybelsus:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

Last edited: Oct 19, 2024 at 11:17 AM
35 8mike.trainer_LA, sarah_nash92, FitDadDave and 32 others
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KarenAZ_mom
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Aug 2024
Scottsdale, AZ
Oct 19, 2024 at 9:34 AM#29

Want to share my personal experience related to Has anyone dealt with rybelsus since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 263 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 63 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Has anyone dealt aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

2 8LibrarianMeg, bri_stats
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emma_london
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Oct 2024
London, UK
Oct 19, 2024 at 9:51 AM#30

Just wanted to say — for anyone reading this Has anyone dealt thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

47 6julia.endo, JessicaM_2024, TomFromTexas and 44 others
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