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ForumsOral GLP-1 AgonistsDropped my Rybelsus in the toilet this morning - worst day — need advice Page 2

Dropped my Rybelsus in the toilet this morning - worst day — need advice

Dr.PainCLE Mon, Dec 22, 2025 at 4:16 PM 6 replies 998 viewsPage 2 of 2
Dr.NutriCornell
Senior Member
1,345
6,234
Mar 2024
Ithaca, NY
Dec 22, 2025 at 7:06 PM#6

Wait there's going to be a 50mg oral version?? That would be a game changer honestly. I would switch in a heartbeat if the efficacy matched injectable.

32 15emily_PDX, Dr.SleepRoch, laura_annarbor and 29 others
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maria_elpaso
Member
312
1,456
Sep 2024
El Paso, TX
Dec 22, 2025 at 7:23 PM#7

For the travel issue specifically — a few tips that helped me keep using injectable while traveling constantly:

  • FRIO insulin cooling wallets — no refrigeration needed, just soak in water. Keeps pens cool for 48-72 hours.
  • TSA has NEVER given me an actual problem with my Wegovy pens. I keep them in a clear bag with the prescription label visible. Just tell them it's medication.
  • Most hotels will put medication in their kitchen fridge if you ask the front desk.
  • Wegovy pens are actually stable at room temperature (up to 86°F/30°C) for up to 28 days, so for short trips you might not even need refrigeration.
43 9RunnerRach, TrialNerd_Beth, HPLC_Greg and 40 others
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DanielChem_CHI
Senior Member
1,234
5,678
Mar 2024
Chicago, IL
Dec 22, 2025 at 7:40 PM#8

Ok this is all super helpful. It sounds like switching to oral at my current dose (1.7mg injectable) would be a downgrade in efficacy, and the daily fasting requirement might actually be MORE of a hassle than weekly injections.

I think I'll stick with injectable and try the FRIO wallet for travel. And keep my eye out for when/if the higher-dose oral formulation gets approved.

Thanks everyone — saved me from making a mistake! 🙏

Last edited: Dec 22, 2025 at 9:40 PM
14 21patPC_UT, Dr.DermMIA, fiona_VT and 11 others
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wendy_avl
Member
245
1,123
Oct 2024
Asheville, NC
Dec 22, 2025 at 7:57 PM#9

Smart decision. One more data point: the oral 50mg formulation from OASIS 1 also had higher rates of GI side effects compared to injectable 2.4mg in cross-trial comparisons. The 50mg pill delivers a LOT of semaglutide to the stomach lining even if only 1% is absorbed systemically, and that local GI exposure may cause more nausea/vomiting. Something to factor in if/when it becomes available.

— pharma_data_guy | PharmD | GLP-1 pharmacology nerd
3 15PharmHunterJen, TomTeleRx, DoseLogDan
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