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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 10

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 10 of 10
jim_asheville
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Asheville, NC
Jul 22, 2024 at 10:10 PM#46

Slightly tangential to Molecular dynamics but TrialTracker_MD reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

21 21MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 18 others
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Dr.RheumBOS
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Jul 22, 2024 at 10:27 PM#47

Saving this for reference. Quality thread.

9 14wei_SG, cory_ATX, lori_vegas and 6 others
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sophie_paris
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Paris, FR
Jul 22, 2024 at 10:44 PM#48

Want to share my personal experience related to Molecular dynamics simulations since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 259 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 59 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Molecular dynamics aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Jul 23, 2024 at 3:44 AM
8 7MariaRD, AussieAnna, BethLabQueen and 5 others
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Dr.NateNeph
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Houston, TX
Jul 22, 2024 at 11:01 PM#49

Relevant to Molecular dynamics simulations — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

45 0B12Beth, RickReta_CO, PharmHunterJen and 42 others
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DoseLogDan
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Feb 2025
Montana
Jul 22, 2024 at 11:18 PM#50

Want to share my personal experience related to Molecular dynamics simulations since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 276 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 66 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Molecular dynamics aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

34 13carlos_SATX, sophie_paris, mel_PDX and 31 others
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