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ForumsPharmacology & MechanismsReceptor internalization and recycling — my results so far Page 3

Receptor internalization and recycling — my results so far

SleepFixSam Sun, Aug 4, 2024 at 8:16 AM 18 replies 1,913 viewsPage 3 of 4
tyler_CSCS
Member
567
2,567
Jun 2024
Phoenix, AZ
Aug 4, 2024 at 12:31 PM#11

HPLC_Greg — wow. This community is amazing.

13 13sean_dublin, hannah_MT, Dr.SportsMedIN and 10 others
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NurseLeah_Nash
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278
1,234
Sep 2024
Nashville, TN
Aug 4, 2024 at 12:48 PM#12

Slightly tangential to Receptor internalization but SleepFixSam reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Aug 4, 2024 at 1:48 PM
49 19BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 46 others
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marco_milano
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345
1,456
Jul 2024
Milan, IT
Aug 4, 2024 at 1:05 PM#13

Thanks for sharing this, SleepFixSam. A few questions about your Receptor internaliza experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Receptor intern?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Aug 4, 2024 at 5:05 PM
41 3Dr.LipidDallas, alex_tucson, kevin_tulsa and 38 others
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SleepFixSam
Member
212
678
Nov 2024
Hawaii
Aug 4, 2024 at 1:22 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Receptor internalization.

To answer NurseLeah_Nash: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

26 10denise_HTX, raj_cambridge, ingrid_STO and 23 others
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labquiet_amy
Senior Member
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6,789
Mar 2024
Cambridge, MA
Aug 4, 2024 at 1:39 PM#15

Relevant to Receptor internalization and — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

2 1pete_manc_UK, anna.melb_AU
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