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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 11

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 11 of 11
pam_columbus
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Columbus, OH
Dec 17, 2024 at 9:41 PM#51

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Biased agonism at GLP-1R .

To answer pam_columbus: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Dec 18, 2024 at 3:41 AM
35 19kevin_tulsa, Dr.PainCLE, mike_mealprep and 32 others
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Dr.LeslieOBGYN
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May 2024
Dallas, TX
Dec 17, 2024 at 9:58 PM#52

Bookmarked 📌 The Biased agonism at info in this thread is essential. Coming back to this for sure.

Last edited: Dec 18, 2024 at 3:58 AM
29 1FranDenver, Dr.BariatricHTX, LindaRN_retired and 26 others
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AussieAnna
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Jun 2024
Sydney, AU
Dec 17, 2024 at 10:15 PM#53

Reading this thread on Biased agonism at GLP-1R hits close to home. Night shift nurse — I started at 279 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 54 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Biased agonism at — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Dec 17, 2024 at 11:15 PM
3 18LibrarianMeg, bri_stats, pete_manc_UK
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TirzTom
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Feb 2024
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Dec 17, 2024 at 10:32 PM#54

Adding my data to this Biased agonism at GLP-1R discussion:

MetricBaselineMonth 3Month 8
Weight250 lbs240 lbs195 lbs
A1C6.4%5.8%5.4%
hsCRP4.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Last edited: Dec 18, 2024 at 2:32 AM
22 19SandraNC_45, Dr.EndoIndy, tom_AK and 19 others
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paul_denver
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May 2024
Denver, CO
Dec 17, 2024 at 10:49 PM#55

Reading this thread on Biased agonism at GLP-1R hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Biased agonism at — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Dec 18, 2024 at 4:49 AM
27 23kim_atl_prep, sarah_TO, wendy_avl and 24 others
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