Orforglipron and hepatic first-pass metabolism

Congrats julia.endo!! Keep going — you're doing incredible. 🎉

Saving this for reference. Top-tier content.

Want to share my personal experience related to Orforglipron and hepatic since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 254 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 44 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Orforglipron and aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Relevant to Orforglipron and hepatic — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 215 → 115 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to Orforglipron and hepatic since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 271 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 51 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Orforglipron and aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.