Oct 20, 2025 at 7:05 PM#26
Can confirm — same results here.
27 10rachel_ABQ, traveltech_sara, AttorneyGrant and 24 others
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Oct 20, 2025 at 7:22 PM#27
sarah_TO said:I started my GLP-1 journey in October 2024 at 250 lbs with prediabetes and hypertension
Gonna push back on this one. GLP-1 and gluconeogenesis what is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.
Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.
Last edited: Oct 20, 2025 at 8:22 PM
17 23jim_asheville, matt_MKE, Dr.ReproEndo and 14 others
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Oct 20, 2025 at 7:39 PM#28
Want to share my personal experience related to GLP-1 and gluconeogenesis since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 256 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 10 months later: I am down 71 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1 and gluconeoge aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
Last edited: Oct 20, 2025 at 10:39 PM
4 2ricardo_MIA, BrianDallas92, labquiet_amy and 1 other
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Oct 20, 2025 at 7:56 PM#29
Saving this for reference. Quality thread.
49 20andrew_nyc, Dr.EndoEP, GraceAZ_72 and 46 others
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Oct 20, 2025 at 8:13 PM#30
paige_pharma — that is really helpful context on GLP-1 and gluconeogenesis. Follow-up question: how long did you wait before increasing your dose?
I am in a similar situation (week 4) and trying to set realistic expectations.
Last edited: Oct 21, 2025 at 12:13 AM
7 14cory_ATX, lori_vegas, Dr.PulmRoch and 4 others
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