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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with so the drug literally changes your brain?? that is wild? Page 2

Has anyone dealt with so the drug literally changes your brain?? that is wild?

Dr.Martinez Wed, Sep 10, 2025 at 1:38 PM 19 replies 1,556 viewsPage 2 of 4
BrianDallas92
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Sep 10, 2025 at 4:28 PM#6

Yep. My endo said the same thing about Has anyone dealt.

40 1Dr.PathRoch, mona_PHX, andrew_nyc and 37 others
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Dr.Martinez
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Sep 10, 2025 at 4:45 PM#7

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with so.

To answer Dr.PainCLE: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

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Dr.NateNeph
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Sep 10, 2025 at 5:02 PM#8

Adding my data to this Has anyone dealt with so discussion:

MetricBaselineMonth 3Month 8
Weight254 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

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Dr.ObesityMed
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Sep 10, 2025 at 5:19 PM#9

+1 to Dr.Martinez. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Has anyone dealt with so.

Last edited: Sep 10, 2025 at 11:19 PM
8 5PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 5 others
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KevinCompounds
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Sep 10, 2025 at 5:36 PM#10

Slightly tangential to Has anyone dealt with so but dan_philly reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

38 18NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 35 others
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