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ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — anyone have experience? Page 6

Why does it stop working after a while for some people — anyone have experience?

kim_atl_prep Thu, Sep 18, 2025 at 5:27 PM 38 replies 2,109 viewsPage 6 of 8
LibrarianMeg
Senior Member
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Mar 2024
Baltimore, MD
Sep 19, 2025 at 1:57 AM#26

Reading this thread on Why does it stop working hits close to home. Night shift nurse — I started at 295 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 70 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Why does it stop — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Sep 19, 2025 at 3:57 AM
28 16Dr.NateNeph, PharmD_Rodriguez, julia.endo and 25 others
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RickReta_CO
Member
312
1,234
Jan 2025
Colorado
Sep 19, 2025 at 2:14 AM#27

COA_Karl — that is really helpful context on Why does it stop working. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

7 0jim_asheville, matt_MKE, Dr.ReproEndo and 4 others
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AttorneyGrant
Member
567
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Apr 2024
Washington, DC
Sep 19, 2025 at 2:31 AM#28

Reading this thread on Why does it stop working hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Why does it stop — take the leap. It was the best health decision I have ever made. ❤️

48 3JenMemphis, pat_auckland, Dr.GastroMayo and 45 others
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fiona_glasgow
Member
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Aug 2024
Glasgow, UK
Sep 19, 2025 at 2:48 AM#29

AttorneyGrant — that is really helpful context on Why does it stop working. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

1 15JessicaH_TX
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tom_AK
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Jan 2026
Anchorage, AK
Sep 19, 2025 at 3:05 AM#30

Reading this thread on Why does it stop working hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Why does it stop — take the leap. It was the best health decision I have ever made. ❤️

47 21Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 44 others
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