Tachyphylaxis vs tolerance — 12 month update

Want to share my personal experience related to Tachyphylaxis vs tolerance 12 since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 257 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 47 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Tachyphylaxis vs aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

Adding my data to this Tachyphylaxis vs discussion:

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

nick_SD_fit — wow. I've been looking for this exact info for weeks.

ChrisMacros said:

Tachyphylaxis vs is exactly what I've been researching

This is exactly right. ChrisMacros articulated what I have been trying to explain to my doctor for months. The Tachyphylaxis vs aspect is the most important factor.