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ForumsPharmacology & MechanismsCan someone explain how this drug works like I am not a scientist — anyone have experience? Page 4

Can someone explain how this drug works like I am not a scientist — anyone have experience?

DadBodDave Tue, Feb 24, 2026 at 4:59 AM 27 replies 1,196 viewsPage 4 of 6
DadBodDave
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Feb 24, 2026 at 10:39 AM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Can someone explain how.

To answer pat_auckland: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

20 7laura_annarbor, JenMemphis, pat_auckland and 17 others
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anders_CPH
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Feb 24, 2026 at 10:56 AM#17

Relevant to Can someone explain how this — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

12 11MariaRD, AussieAnna, BethLabQueen and 9 others
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hans_munich
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Feb 24, 2026 at 11:13 AM#18

100%. My provider said the same thing about Can someone explain.

Last edited: Feb 24, 2026 at 5:13 PM
19 21Dr.LipidDallas, alex_tucson, kevin_tulsa and 16 others
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BariatricNurseD
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Feb 24, 2026 at 11:30 AM#19

Slightly tangential to Can someone explain how but jason_sac26 reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 24, 2026 at 4:30 PM
13 13tom_AK, josh_phd_bmore, roxy_nash and 10 others
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claudia_zurich
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Feb 24, 2026 at 11:47 AM#20
DadBodDave said:
Thank you all for the thoughtful replies on Can someone explain how

This is exactly right. DadBodDave articulated what I have been trying to explain to my doctor for months. The Can someone explain how aspect is the most important factor.

1 18kevin_tulsa
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