GLP-1/GIP receptor co-agonism — anyone have experience?

Want to share my personal experience related to GLP-1/GIP receptor co-agonism since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 248 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 68 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1/GIP receptor aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Moderator note: Please keep vendor-specific discussions in the Vendor Reviews section.

I have cleaned up a few off-topic posts. 👍

Adding my data to this GLP-1/GIP receptor discussion:

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

RunnerRach — wow. This community is amazing.

Dr.SurgeonPGH said:

GLP-1/GIP receptor is exactly what I've been researching

This is exactly right. Dr.SurgeonPGH articulated what I have been trying to explain to my friends for months. The GLP-1/GIP receptor aspect is what made the difference for me.