Jan 10, 2026 at 11:07 AM#16
Congrats fiona_VT!! You should be so proud of yourself. 🎉
20 19Dr.PainCLE, mike_mealprep, NicoleRaleigh and 17 others
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Jan 10, 2026 at 11:24 AM#17
CryptoCarl's experience with PK/PD modeling for resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I am on a different medication. But the overall trajectory has been remarkably similar. Down 51 lbs in 6 months.
One thing I would add that CryptoCarl did not mention: my sleep quality improved dramatically.
33 13JessicaM_2024, TomFromTexas, mike.trainer_LA and 30 others
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Jan 10, 2026 at 11:41 AM#18
Bookmarked 📌 The PK/PD modeling for info in this thread is essential. Coming back to this for sure.
Last edited: Jan 10, 2026 at 5:41 PM
20 2BrianDallas92, labquiet_amy, emily_PDX and 17 others
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Jan 10, 2026 at 11:58 AM#19
Clinical perspective on PK/PD modeling for tirzepatide anyone:
I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.
For this specific question, I would recommend: reviewing the relevant clinical guidelines.
5 12julia.endo, JessicaM_2024, TomFromTexas and 2 others
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Jan 10, 2026 at 12:15 PM#20
Subscribing to this thread. PK/PD modeling for is exactly what I've been researching. 🙏
34 18lisa_labSD, adam_van, Dr.SurgeonPGH and 31 others
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