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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — modeling data Page 2

Steady-state concentrations across dose tiers — modeling data

SarahChen_PharmD Fri, Jun 5, 2026 at 10:13 PM 23 replies 323 viewsPage 2 of 5
Dr.SleepRoch
Senior Member
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Apr 2024
Rochester, MN
Jun 6, 2026 at 1:03 AM#6

Subscribing to this thread. Steady-state is exactly what I've been researching. 🙏

42 2sarah_TO, wendy_avl, jason_paloalto and 39 others
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SarahChen_PharmD
VIP Member
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Dec 2023
San Diego, CA
Jun 6, 2026 at 1:20 AM#7

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Steady-state.

To answer Dr.CardioMD: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Jun 6, 2026 at 4:20 AM
6 20NurseKim_ATL, paul_denver, TinaHashiRN and 3 others
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DoseLogDan
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Feb 2025
Montana
Jun 6, 2026 at 1:37 AM#8

Adding my data to this Steady-state discussion:

MetricBaselineMonth 4Month 8
Weight274 lbs249 lbs199 lbs
A1C6.8%6.2%5.4%
hsCRP8.03.00.8

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Jun 6, 2026 at 2:37 AM
29 22mel_PDX, Dr.AddMedPHL, newstart_MO and 26 others
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TomTeleRx
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Feb 2025
Delaware
Jun 6, 2026 at 1:54 AM#9

+1 to SarahChen_PharmD. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Steady-state.

24 12HPLC_Greg, LibrarianMeg, bri_stats and 21 others
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NurseAsh_DET
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Sep 2024
Detroit, MI
Jun 6, 2026 at 2:11 AM#10

Slightly tangential to Steady-state but KarenAZ_mom reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 6, 2026 at 8:11 AM
9 0emily_PDX, Dr.SleepRoch, laura_annarbor and 6 others
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