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ForumsRetatrutide & Triple AgonistsTriple agonist sounds scary - is it actually safe

Triple agonist sounds scary - is it actually safe

nick_newbie Thu, Apr 23, 2026 at 6:55 PM 3 replies 480 viewsPage 1 of 1
nick_newbie
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Apr 23, 2026 at 8:20 PM#1

Can I just vent for a second about triple agonist sounds scary - is?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily — just solidarity. Anyone else going through this right now?

36 6robert_kc, dan_philly, MeganSA_TX and 33 others
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NeuroNate
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Apr 23, 2026 at 8:37 PM#2

nick_newbie's experience with Triple agonist sounds resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 52 lbs in 7 months.

One thing I would add that nick_newbie did not mention: the relationship with food fundamentally changed.

35 7wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 32 others
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EndoResFellow
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Apr 23, 2026 at 8:54 PM#3

Thanks for sharing this, nick_newbie. A few questions about your Triple agonist experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Triple agonist?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

46 12paul_denver, TinaHashiRN, robert_kc and 43 others
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nick_newbie
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Apr 23, 2026 at 9:11 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Triple agonist sounds.

To answer EndoResFellow: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

35 0LarryQC_SD, wanda_boise, NurseAsh_DET and 32 others
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VendorMark
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Apr 23, 2026 at 9:28 PM#5

Relevant to Triple agonist sounds scary - — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 225 → 95 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Apr 23, 2026 at 11:28 PM
23 1claudia_zurich, nancy_portland, rick_sfbay and 20 others
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